Effect of Atorvastatin and Vitamin D against Multi-drug Resistant Staphylococcus spp and Escherichia coli Isolated from Bovine Mastitis Cases

Background: In the current scenario, emergence of antimicrobial resistance has made it difficult to treat bacterial infections alone using antibacterial agents. Methods: Milk samples collected from 100 mastitis affected cows August 2018 June 2019 and were stored at 4°C. After species confirmation, isolates subjected ABST screened for genes - mecA, blaTEM PCR. Minimum Inhibitory Concentration (MIC) tetracycline ampicillin determined against both Staphylococcus spp E. coli, in combination with atorvastatin, vitamin D by a modified microdilution method. Result: coli showed 80.65% 85.71%, 100% 85.71% ampicillin, respectively. Atorvastatin did not display effects as sole agents species. However, there was significant decrease MIC when combined atorvastatin but tetracycline.